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  • AUTOLOGOUS IMMUNE COMPLEX NEPHRITIS INDUCED WITH

    ity of such test material to inhibit the staining by anti-RTE of glomerular deposited RTE-c~5 in kidneys from rats with AIC nephritis. A single pool of anti-RTE was used to stain the glomerular deposited RTE-a5 as described above. The kidneys from three rats with advanced

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  • Renal iron accumulation occurs in lupus nephritis and iron ...

    2017-10-9 · Lupus nephritis is a serious complication of the autoimmune disease systemic lupus erythematosus (SLE), affecting up to 50% percent of patients 1. Current treatments for lupus nephritis focus on immunosuppressive and anti-inflammatory approaches, which carry significant side effects and yet are sub-optimally effective, with remission slow or partial, and relapses …

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  • Identification and characterization of antigen-specific ...

    2020-12-4 · Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) 1,2. Affecting approximately 50% of SLE patients, it …

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  • Tubulointerstitial nephritis antigen-like 1 protein is ...

    2017-3-21 · Tubulointerstitial nephritis antigen-like 1 protein (TINAGL1), is a matricellular protein, known to play role in cell adhesion and cell receptor interaction. Research related to TINAGL1 is limited to cell culture and animal models. Demonstration of TINAGL1 as a positive regulator of angiogenesis and its expression in the decidua of postimplantation ...

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  • Nephritis: Types, causes, and symptoms

    2020-2-4 · nephritis [1]. Lupus nephritis is usually manifested by proteinuria, active urinary sediment, hypertension, and renal failure and is a serious complication with more than 50% occurrence in SLE patients [2]. The causes of many individual SLE pathologies are poorly understood. Traditional therapy includes glucocorticoids, cyclophos-

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  • Efficacy of mesenchymal stem cells in animal models of ...

    2020-6-18 · Two different time points, prior to nephritis onset and at established disease, were included in the analysis for each mouse strain based on the age of disease onset . The penetrance of nephritis was assessed by H+E staining for all mice. B6.NZMSle123 (12 weeks), NZB/W (18 weeks) and BXSB.

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  • Design and application of single-cell RNA sequencing to ...

    2020-2-4 · Background. Lupus nephritis is usually manifested by proteinuria, active urinary sediment, hypertension, and renal failure and is a serious complication with more than 50% occurrence in systemic lupus erythematosus patients. Mesenchymal stem cells (MSC) present remarkable immunomodulatory ability, and these cells are potential therapeutic agents ...

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  • Proteomic analysis in lupus mice identifies Coronin-1A as ...

    2019-4-6 · # Hikari will use the above plus the following to setup connection pooling spring.datasource.type = com.zaxxer.hikari.HikariDataSource spring.datasource.hikari.minimum-idle= 5 spring.datasource.hikari.maximum-pool-size= 15 spring.datasource.hikari.auto true

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  • A survey of avian sera from Northern Ireland for antibody ...

    2018-5-31 · Serum neutralisation test for determination of antibody to ANV A working pool of virus was titrated in CK cell cultures and standardised to give 200 TCID50 of virus per 0.5 ml after 72 hours' incubation. Doubling dilutions of serum (0.6 ml volumes) from 1 in 12 to 1 in 49, 152 were prepared and equal volumes of virus (200 TCIDS0) were added ...

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  • Changes of memory B- and T-cell subsets in lupus nephritis ...

    [SLEDAI] > 6, urine protein > 1 g/day or > 2-fold increase with active urinary sediment) and 18 patients in remission (inactive-LN, SLEDAI 6, urine protein < 1 and normal £ urinary sediment) [23]. All but one active-LN patients had additional SLE symptoms: hematologic (88%, mostly lym-phopenia), joint symptoms (50%), skin lesions (50%), and

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  • Current management of lupus nephritis - ScienceDirect

    2013-6-1 · The LUpus Nephritis Assessment with Rituximab (LUNAR) trial was a Phase III study including 144 Class III or IV LN patients . All patients received GC (2 g IV MP, followed by 0.75 mg kg −1 day −1 of prednisolone) and MMF (up to 3 g day −1) as a background therapy. RTX (two infusions of 1 g, 15 days apart with re-treatment 6 months later ...

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  • Tubulointerstitial nephritis antigen-like 1 protein is ...

    2017-3-21 · Tubulointerstitial nephritis antigen-like 1 protein (TINAGL1), is a matricellular protein, known to play role in cell adhesion and cell receptor interaction. Research related to TINAGL1 is limited to cell culture and animal models. Demonstration of TINAGL1 as a positive regulator of angiogenesis and its expression in the decidua of postimplantation mouse uterus, prompted us to …

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  • Remission of proliferative lupus nephritis following B ...

    2005-2-3 · As shown in Figure 1, when partial remission of nephritis was clinically evident, the percentages of CD69‐expressing and HLA–DR–expressing cells among CD4+ T cells were significantly decreased (P = 0.008 and P = 0.02, respectively, by Wilcoxon's signed rank test), while expression of the CD40L costimulatory molecule was almost completely ...

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  • 222 Circulating pentraxin3-specific B cells are decreased ...

    Background Pentraxin3 (PTX3) is overexpressed in kidneys of patients developing lupus nephritis (LN). Active LN is associated with reduced anti-PTX3 antibodies. However, abnormalities of B cell differentiation against PTX3 have not been characterized in systemic lupus erythematosus (SLE). The aim of our study is to characterize PTX3-specific (PTX3+) B cells in peripheral blood of SLE …

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  • High prevalence of anti-C1q antibodies in biopsy-proven ...

    2006-7-28 · The absence of lupus nephritis was defined as normal urinalysis results and creatinine levels. Inactivity of pre-existing lupus nephritis was defined as either normal or continuously decreasing or stable values for proteinuria, erythrocyturia (<20 erythrocytes/field) and creatinine during the 6 months preceding the analysis for anti-C1q.

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  • Development of a Novel Renal Activity Index of Lupus ...

    lupus nephritis in children and young adults hermine i. brunner,1 michael r. bennett,1 khalid abulaban,1 marisa s. klein-gitelman,2 kathleen m. o’neil,3 lori tucker,4 stacy p. ardoin,5 kelly a. rouster-stevens,6 karen b. onel,7 nora g. singer,8 b. anne eberhard,9 lawrence k. jung,10 lisa imundo,11 tracey b. wright,12 david witte,1 brad h. rovin,5

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  • IMMUNOLOGICAL STUDIES CONCERNING THE NEPHRITIS

    pH 7.4 phosphate-buffered saline. After the last wash, approximately 1.0 cc of precipitate was suspended in 10 cc of pH 6.9 buffer with 0.003 u MgC12. 1.0 mg of DNase was added to the suspension and incubated at 37°C for 1 hr (23). The suspension was then dialyzed over-

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  • Poultry - GD Animal Health

    Panel respiratory PCR for poultry (swab) pooled 1-6 (Mycoplasma gallisepticum, Mycoplasma synoviae MSH, Turkey rhinotracheitis (TRT), Infectious laryngotracheïtis (ILT), Infectious bronchitis virus, Avibacterium paragallinarum (Coryza))

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  • Changes of memory B- and T-cell subsets in lupus nephritis ...

    [SLEDAI] > 6, urine protein > 1 g/day or > 2-fold increase with active urinary sediment) and 18 patients in remission (inactive-LN, SLEDAI 6, urine protein < 1 and normal £ urinary sediment) [23]. All but one active-LN patients had additional SLE symptoms: hematologic (88%, mostly lym-phopenia), joint symptoms (50%), skin lesions (50%), and

    Get Price
  • Current management of lupus nephritis - ScienceDirect

    2013-6-1 · The LUpus Nephritis Assessment with Rituximab (LUNAR) trial was a Phase III study including 144 Class III or IV LN patients . All patients received GC (2 g IV MP, followed by 0.75 mg kg −1 day −1 of prednisolone) and MMF (up to 3 g day −1) as a background therapy. RTX (two infusions of 1 g, 15 days apart with re-treatment 6 months later ...

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  • Tubulointerstitial nephritis antigen-like 1 protein is ...

    2017-8-25 · Tubulointerstitial nephritis antigen-like 1 protein is downregulated in the placenta of pre-eclamptic women Sheon Mary1, Mahesh J. Kulkarni1*, Savita S. Mehendale2, Sadhana R. Joshi3 and Ashok P. Giri1* Abstract Background: Tubulointerstitial nephritis antigen-like 1 protein (TINAGL1), is a matricellular protein, known to play

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  • Discovery and Qualification of Candidate Urinary ...

    2018-12-10 · In multivariate regression analyses, duration of nephritis symptoms > 6 months prior to biopsy, s-creatinine > 140 micromol/l, diffuse proliferative glomerulonephritis, and tubular atrophy emerged as the strongest combination of independent risk factors (relative hazard ratios: 9.3, 5.6, 8.9, and 3.1, respectively).

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  • use of gallium-67 scintigraphy in the diagnosis of acute ...

    Introduction. Acute interstitial nephritis (AIN) accounts for up to 15% of kidney biopsies performed to investigate unexplained acute kidney injury (AKI) [1, 2].Immunoallergic drug reaction is by far the most common cause of AIN, accounting for 75–90% of cases [].Recognition of AIN is important, since early withdrawal of the causative drug and possibly corticosteroids can lead to recovery of ...

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  • What causes chronic tubulointerstitial nephritis ...

    2020-11-4 · Chronic tubulointerstitial nephritis (drug variant), unlike many other variants of chronic nephropathies, is potentially preventable. Most of his cases are associated with long-term intake of NSAIDs and non-narcotic analgesics; to refer to them use the term analgesic nephropathy.

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  • [Official] Myron L Company - Manufacturer of Water Test ...

    Myron L® Company - Manufacturer of hand-held and process control water testing instruments for many applications. All Model specifications and information online.

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  • Development of a Novel Renal Activity Index of Lupus ...

    lupus nephritis in children and young adults hermine i. brunner,1 michael r. bennett,1 khalid abulaban,1 marisa s. klein-gitelman,2 kathleen m. o’neil,3 lori tucker,4 stacy p. ardoin,5 kelly a. rouster-stevens,6 karen b. onel,7 nora g. singer,8 b. anne eberhard,9 lawrence k. jung,10 lisa imundo,11 tracey b. wright,12 david witte,1 brad h. rovin,5

    Get Price
  • IMMUNOLOGICAL STUDIES CONCERNING THE NEPHRITIS

    pH 7.4 phosphate-buffered saline. After the last wash, approximately 1.0 cc of precipitate was suspended in 10 cc of pH 6.9 buffer with 0.003 u MgC12. 1.0 mg of DNase was added to the suspension and incubated at 37°C for 1 hr (23). The suspension was then dialyzed over-

    Get Price
  • Poultry - GD Animal Health

    Panel respiratory PCR for poultry (swab) pooled 1-6 (Mycoplasma gallisepticum, Mycoplasma synoviae MSH, Turkey rhinotracheitis (TRT), Infectious laryngotracheïtis (ILT), Infectious bronchitis virus, Avibacterium paragallinarum (Coryza))

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  • Lupus nephritis is linked to disease-activity associated ...

    In these faecal samples, patients with lupus had 2.6-fold overall sIgA elevations vs controls (Welch test, p=0.002) . Furthermore, the elevations of faecal IgM in patients with lupus, as well as the increases in faecal IgG, provide additional circumstantial evidence of an impairment of the epithelial barrier in these patients ( figure 1E, F ).

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  • Interpretation of Crossmatch reports in a patient with ...

    2018-8-14 · Lupus nephritis is a frequent complication of systemic lupus erythematosus and is more common and severe in children. This is a disease of the immune system characterized by T cell, B cell, and complement activation, as well as immune complex formation and deposition. The introduction of steroids and later cyclophosphamide transformed lupus nephritis from a fatal to a …

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  • Induction Therapy for Lupus Nephritis: the Highlights ...

    Introduction. Acute interstitial nephritis (AIN) accounts for up to 15% of kidney biopsies performed to investigate unexplained acute kidney injury (AKI) [1, 2].Immunoallergic drug reaction is by far the most common cause of AIN, accounting for 75–90% of cases [].Recognition of AIN is important, since early withdrawal of the causative drug and possibly corticosteroids can lead to recovery of ...

    Get Price
  • use of gallium-67 scintigraphy in the diagnosis of acute ...

    1. Assistant Professor of Medicine, McGill University; Director, the Department of Metabolism, the Montreal General Hospital, Montreal. Canadian Medical Association Journal , 01 Jun 1931 , 24(6…

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  • LABORATORY TESTS AND THE GENERAL PRACTITIONER

    Myron L® Company - Manufacturer of hand-held and process control water testing instruments for many applications. All Model specifications and information online.

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  • [Official] Myron L Company - Manufacturer of Water Test ...

    2018-8-27 · 1、在学习从文件读取数据中,写了个示例代码,读取不在同一个目录的file.txt,运行后报这个Python OSError: [Errno 22] Invalid argument:错误:(1)、首先,在F盘的python_stu中新增了一个file.txt,同时在F盘的python_stu文件目录底下新增一个file ...

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  • Interstitial nephritis: MedlinePlus Medical Encyclopedia

    2021-7-2 · Interstitial nephritis can cause mild to severe kidney problems, including acute kidney failure. In about half of cases, people will have decreased urine output and other signs of acute kidney failure. Symptoms of this condition may include: Blood in the urine. Fever.

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  • Acute nephritic syndrome: MedlinePlus Medical Encyclopedia

    2021-7-6 · Acute nephritic syndrome is often caused by an immune response triggered by an infection or other disease. The inflammation affects the function of the glomerulus. This is the part of the kidney that filters blood to make urine and remove waste. As a result, blood and protein appear in the urine, and excess fluid builds up in the body.

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  • Glomerulonephritis - Symptoms and causes - Mayo Clinic

    2018-12-12 · the test serum, adding ethylene-diamine-tetra-acetic acid (EDTA) or dithiothreitol (DTT) [5,6]. The first method involves flow cytometry using micro-particles, each coated with soluble single HLA antigen to detect and measure the channel shift associated with antibody binding to the beads. It is highly

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  • Careful Interpretation of HLA Typing and Cross-Match Tests ...

    1. Assistant Professor of Medicine, McGill University; Director, the Department of Metabolism, the Montreal General Hospital, Montreal. Canadian Medical Association Journal , 01 Jun 1931 , 24(6…

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  • LABORATORY TESTS AND THE GENERAL PRACTITIONER

    2008-8-15 · LPS induces acute phase responses by stimulating the production of cytokines, such as IL-6 and IL-1, and these cytokines induce the synthesis of various acute phase proteins through several distinct signaling pathways, which involve different transcription factors such as NF-kB, C/EBP (CAAT/enhancer binding protein) and the STAT family (48–50).

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  • Dissection of Genetic Mechanisms Governing the

    2019-2-26 · Jedis的使用及配置优化 Jedis是什么 jedis就是基于java语言的redis客户端,集成了redis的命令操作,提供了连接池管理。 redis-cli是redis官方提供的客户端,可以看作一个shell程序,它可以发送命令对redis进行操作。

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